Optimizing clobazam treatment in patients with Lennox–Gastaut syndrome

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Optimizing clobazam treatment in patients with Lennox–Gastaut syndrome

Given the complexities managing Lennox-Gastaut syndrome (LGS)-comorbid conditions, multiple associated seizure types that tend to be refractory to treatment-dosage optimization of antiepileptic drug (AED) treatment is a challenge. In the absence of clinical trial data on optimization of AED dosage in patients with LGS, dose titration is guided by personal experience, anecdotal evidence, and spe...

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Treatment of febrile seizures with intermittent clobazam.

Fifty children, 24 female and 26 male, with ages varying from 6 to 72 months (mean = 23.7 m.) that experienced at least one febrile seizure (FS) entered a prospective study of intermittent therapy with clobazam. Cases with severe neurological abnormalities, progressive neurological disease, afebrile seizures, symptomatic seizures of other nature, or seizures during a central nervous system infe...

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ژورنال

عنوان ژورنال: Epilepsy & Behavior

سال: 2018

ISSN: 1525-5050

DOI: 10.1016/j.yebeh.2017.10.003